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1.
Archives of Aesthetic Plastic Surgery ; : 74-78, 2016.
Article in English | WPRIM | ID: wpr-196656

ABSTRACT

BACKGROUND: Patients with deviated nose frequently present concomitant nasal bone as well as septal deviation. Many surgical methods have been developed to address such septal deviation, along with various osteotomy techniques to correct bone deviation. The authors performed medial and paramedian osteotomies to treat deviated nose with mild hump, and utilized the acquired wedge shaped bone graft to achieve septal reposition and bony vault correction. METHODS: From October 2014 through June 2015, 10 patients with nasal bone deviation that showed sufficient lateral nasal wall angle but deviated dorsum and septum on their preoperative facial computed tomography were included in this study. The authors performed open rhinoplasty to expose the planned osteotomy site, and conducted medial and paramedian osteotomy that resulted in the separation of a wedge-shaped bone fragment. Bony septum deviation was then treated with the swing door maneuver, and the resected 2 to 3 mm portion of the nasal bone was stabilized by inserting the wedge-shaped bone graft acquired from the previous osteotomy procedures. Consecutive clinical examinations were followed on postoperative 1, 3, and 6 months to observe any recurrences. RESULTS: All patients were satisfied with their surgical results, and no recurrent deviations were noted. CONCLUSIONS: Precise bone resection and transposition is essential for a successful corrective rhinoplasty. However, medial and lateral osteotomy are not mandatory procedures in all cases, and the nasal wedge bone graft that was utilized to support the treated septal bone may have aided in sustaining the surgical correction.


Subject(s)
Humans , Bone Transplantation , Nasal Bone , Nose , Osteotomy , Recurrence , Rhinoplasty , Transplants
2.
Archives of Craniofacial Surgery ; : 233-236, 2016.
Article in English | WPRIM | ID: wpr-89533

ABSTRACT

Scalp defect management is complicated secondary to reduced laxity in the scalp and forehead area. For reconstruction of larger defects with exposed bone and loss of the periosteal layer, free flap reconstruction is one option for single-stage surgery, although the procedure is lengthy and includes the possibility of flap loss. We successfully performed a single-stage reconstruction of a large scalp defect using a combination of artificial dermis, split-thickness skin graft, and full-thickness skin graft following wide excision of a cutaneous angiosarcoma, and present our method as one option for the treatment of large oncologic surgical defects in patients who are poor candidates for free flap surgery.


Subject(s)
Humans , Dermis , Forehead , Free Tissue Flaps , Hemangiosarcoma , Methods , Scalp , Skin , Skull , Transplants
3.
Archives of Craniofacial Surgery ; : 90-92, 2016.
Article in English | WPRIM | ID: wpr-163190

ABSTRACT

Pleomorphic adenoma is the most common type of salivary gland tumor and the most common tumor of the parotid gland. Because of its propensity for invasion, pleomorphic adenoma of the parotid requires superficial parotidectomy or total parotidectomy to minimize the risk of tumor recurrence. We report a case of pleomorphic adenoma of the parotid gland with repeated recurrences. A 23-year-old male patient presented with a protruding neck mass. Six years prior to this presentation, the patient had undergone superficial parotidectomy for the removal of pleomorphic adenoma of the right parotid gland at our institution. The patient experienced recurrence at 17 months after the initial resection, which required a total parotidectomy with partial resection of the facial nerve. Pathologic examination revealed histologic findings consistent with pleomorphic adenoma across the surgical specimen from all three of the operations. The patient suffered from facial nerve paralysis, with facial expressions partially recovered over a year.


Subject(s)
Humans , Male , Young Adult , Adenoma, Pleomorphic , Facial Expression , Facial Nerve , Neck , Paralysis , Parotid Gland , Recurrence , Salivary Glands
4.
Archives of Plastic Surgery ; : 489-492, 2015.
Article in English | WPRIM | ID: wpr-21486

ABSTRACT

No abstract available.


Subject(s)
Solitary Fibrous Tumors , Thigh
5.
Archives of Craniofacial Surgery ; : 36-39, 2014.
Article in English | WPRIM | ID: wpr-155890

ABSTRACT

Leiomyosarcoma is a rare form of soft tissue neoplasm, with only 1% to 5% occurring in the head and neck region. Current recommended treatment suggests surgical excision with a wide lateral margin, but no definite guidelines regarding excisional margin have been established yet. Recently, complete excision with a narrow surgical margin has been recommended, and the authors present a case of cutaneous leiomyosarcoma on the face that was successfully managed by complete removal with a narrow excisional margin. A 74-year-old woman presented with a 3 cm sized, rapidly growing cutaneous mass on her right preauricular area. Preoperative biopsy of the skin lesion suggested a cutaneous leiomyosarcoma. The authors performed complete surgical excision with a 1 cm lateral margin, and the resulting skin defect was repaired with bilateral V-Y advancement local flaps. Histopathology and immunohistochemistry evaluation confirmed a moderately differentiated cutaneous leiomyosarcoma, with negative margin involvement. The patient refused of any additional treatment, but showed no locoregional recurrence during the 1.5 years of postoperative follow-up period. With a regular postoperative follow-up, cutaneous leiomyosarcomas may be successfully treated with a narrow surgical margin.


Subject(s)
Aged , Female , Humans , Biopsy , Follow-Up Studies , Head , Immunohistochemistry , Leiomyosarcoma , Neck , Recurrence , Skin , Soft Tissue Neoplasms
6.
Archives of Plastic Surgery ; : 440-444, 2013.
Article in English | WPRIM | ID: wpr-176199

ABSTRACT

BACKGROUND: Axillary osmidrosis is characterized by unpleasant odors originating from the axillary apocrine glands, resulting in psychosocial stress. The main treatment modality is apocrine gland removal. Until now, of the various surgical techniques have sometimes caused serious complications. We describe herein the favorable outcomes of a new method for ablating apocrine glands by minimal subdermal shaving using sclerotherapy with absolute ethanol. METHODS: A total of 12 patients underwent the procedure. The severity of osmidrosis was evaluated before surgery. Conventional subdermal shaving was performed on one side (control group) and ablation by means of minimal subdermal shaving and absolute ethanol on the other side (study group). Postoperative outcomes were compared between the study and control groups. RESULTS: The length of time to removal of the drain was 1 day shorter in the study group than in the control group. There were no serious complications, such as hematoma or seroma, in either group, but flap margin necrosis and flap desquamation occurred in the control group, and were successfully managed with conservative treatment. Six months after surgery, we and our patients were satisfied with the outcomes. CONCLUSIONS: Sclerotherapy using absolute ethanol combined with minimal subdermal shaving may be useful for the treatment of axillary osmidrosis. It can reduce the incidence of seroma and hematoma and allow the skin flap to adhere to its recipient site. It can degrade and ablate the remaining apocrine glands and eliminate causative organisms. Furthermore, since this technique is relatively simple, it takes less time than the conventional method.


Subject(s)
Humans , Apocrine Glands , Axilla , Ethanol , Hematoma , Incidence , Necrosis , Odorants , Sclerotherapy , Seroma , Skin
7.
Archives of Plastic Surgery ; : 329-332, 2012.
Article in English | WPRIM | ID: wpr-50327

ABSTRACT

BACKGROUND: Ankyloglossia or tongue-tie is a congenital anomaly characterized by an abnormally short lingual frenum. Its prevalence in the newborn population is approximately 4%. Its mode of inheritance has been studied in some articles, but no conclusion has been established. Also, no relevant report has been published in Korea. This study was conducted to elucidate the genetic inheritance of ankyloglossia via pedigree analysis. METHODS: In this study, 149 patients with no other congenital anomaly who underwent frenuloplasty between March 2001 and March 2010 were studied. Pedigrees were made via pre- or post-operative history taking, and patients with uncertain histories were excluded. In the patient group that showed a hereditary nature, the male-to-female ratio, inheritance rate, and pattern of inheritance were investigated. RESULTS: One hundred (67.11%) of the patients were male and 49 (32.89%) were female (male-female ratio=2.04:1). Ninety-one (61.07%) patients reported no other relative with ankyloglossia, and 58 (38.93%) patients had a relative with this disease. The inheritance rate was 20.69% in the 58 cases with a hereditary nature. In the group with no family history of ankyloglossia, the male-female ratio was 3.79:1, which significantly differed from that of the group with a family history of ankyloglossia. X-chromosome mediated inheritance and variation in the gene expression was revealed in the pedigree drawn for the groups with hereditary ankyloglossia. CONCLUSIONS: Ankyloglossia has a significant hereditary nature. Our data suggest X-linked inheritance. This study with 149 patients, the first in Korea, showed X-linked inheritance in patients with a sole anomaly.


Subject(s)
Female , Humans , Infant, Newborn , Male , Gene Expression , Genes, X-Linked , Korea , Lingual Frenum , Mouth Abnormalities , Pedigree , Prevalence , Wills
8.
Korean Journal of Pathology ; : 644-649, 2011.
Article in English | WPRIM | ID: wpr-78178

ABSTRACT

Cutaneous myoepithelial neoplasms and papillary eccrine adenomas (PEA) are rare conditions. Malignant tumors within a PEA are even rarer, with only one case reported to date. Herein, we present an extremely rare case of a cutaneous myoepithelial carcinoma arising in a PEA in a 70-year-old man presenting a solid mass in the left buttock. Histopathologically, most of the resected tumor revealed features consistent with the diagnosis of PEA. Some small nests and nodules were intermixed with the PEA and were present adjacent to the PEA. The tumor cells of nests and nodules showed ovoid to spindle shaped nuclei and slightly eosinophilic cytoplasm. Immunohistochemically, they were positive for both epithelial and myogenic markers, consistent with myoepithelioma. An inguinal lymph node with a metastatic lesion showed the same findings of myoepithelioma despite inconspicuous atypia. Our case showed malignant transformation of the myoepithelial cells at the outermost layers of the PEA.


Subject(s)
Aged , Humans , Adenoma , Buttocks , Cytoplasm , Eosinophils , Lymph Nodes , Myoepithelioma , Peas , Skin
9.
Journal of the Korean Cleft Palate-Craniofacial Association ; : 23-26, 2008.
Article in Korean | WPRIM | ID: wpr-18808

ABSTRACT

Salivary duct carcinoma is a high-grade adenocarcinoma arising from the ductal epithelium and has very low prevalence. We report a case of salivary duct carcinoma in high risk group with satisfactory result. A 65-year-old male was referred to our clinic complaining of mass on Rt. cheek. Preoperative CT and MRI shows 2.0x1.9cm sized multilobulated, cystic mass on the superficial lobe of Rt. parotid gland and multiple lymph node enlargement thorough the Rt. internal jugular chain. Total parotidectomy and modified radical neck dissection with adjuvant radiation therapy was performed. Pathologic result was salivary duct carcinoma and resection margin was free. Postoperative radiation therapy with 6400cGy(200cGyx 12 fx) was performed. During the 24-months of follow up periods, recurrence or complications associated with operation and radiation therapy was not observed. Salivary duct carcinoma is rare disease with very poor prognosis. Lymph node metastasis is commonly accompanied at the time of diagnosis. Distant metastasis is the most common cause of death. Total parotidectomy, radical neck disssection and adjuvant radiation therapy can be the appropriate modality for the control of the salivary duct carcinoma especially in high risk group.


Subject(s)
Aged , Humans , Male , Adenocarcinoma , Cause of Death , Cheek , Epithelium , Follow-Up Studies , Lymph Nodes , Neck , Neck Dissection , Neoplasm Metastasis , Parotid Gland , Prevalence , Prognosis , Rare Diseases , Recurrence , Salivary Ducts
10.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 739-742, 2008.
Article in Korean | WPRIM | ID: wpr-194191

ABSTRACT

PURPOSE: Breast augmentation is one of the common procedures in plastic surgery today. The shape, size and insertion plane of the implant is decided preoperatively by physical examination of the breast. Pectus excavatum is one of the most common anomalies of chest wall, characterized by a depression of the anterior chest wall. For patients with a mild type of pectus excavatum, the main purpose of the treatment is aesthetic rather than functional improvement. Two most surgical treatment options for skeletal deformity are the Ravitch technique and minimally invasive Nuss repair. Other options for soft tissue repair are implant insertion and autologous soft tissue augmentation. We performed a surgical operation with Nuss procedures and breast augmentation for a patient with mild pectus excavatum and hypoplastic breast. METHODS: A 32 year-old female was presented with hypoplastic breast. Preoperative chest CT was performed, showing pectus excavatum. After Nuss procedure, we inserted saline implant(275cc textured round breast implant, moderate profile) submuscularly to restore adequately projected breast. RESULTS: Patient's postoperative course was uneventful without any complication. After 6 months of follow-up period, the patient had an excellent result, with high patient satisfaction and no complications. CONCLUSION: For patients with a mild type of pectus excavatum, who do not have cardiopulmonary symptoms and requires for aesthetic improvement, this simple approach with Nuss procedure and breast augmentation achieves excellent aesthetic correction with low complication rate and high patient satisfaction.


Subject(s)
Female , Humans , Breast , Breast Implants , Congenital Abnormalities , Depression , Follow-Up Studies , Funnel Chest , Patient Satisfaction , Physical Examination , Surgery, Plastic , Thoracic Wall , Thorax
11.
Journal of Korean Medical Science ; : 1080-1085, 2006.
Article in English | WPRIM | ID: wpr-174097

ABSTRACT

The ultimate goal in treating zygomatic complex fracture is to obtain an accurate, stable reduction while minimizing external scars and functional deformity. The present authors present our experiences with a single transconjunctival incision and two-point (inferior orbital rim and frontozygomatic suture) fixation in 53 patients with zygomatic complex fracture which were not comminuted. All patients had transconjunctival approaches with lateral canthal extensions, and six out of 53 patients also had an additional small (about less than 2 cm) gingivobuccal incision to achieve an accurate reduction. There were 3 minor complications, and the overall esthetics and functional results were satisfactory with a long term follow-up. Our method has the following advantages in the reduction of zygomatic complex fracture; It leaves only an inconspicuous lateral canthal scar. In addition, it provides excellent simultaneous visualization of the inferior orbital rim and frontozygomatic suture area. Hence, twopoint fixation through a single incision can be performed with a satisfactory stability.


Subject(s)
Middle Aged , Male , Humans , Female , Aged, 80 and over , Aged , Adult , Adolescent , Zygomatic Fractures/surgery , Treatment Outcome , Minimally Invasive Surgical Procedures/instrumentation , Osteotomy/instrumentation , Fracture Fixation, Internal/instrumentation , Conjunctiva/surgery , Bone Plates
12.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 205-212, 2006.
Article in Korean | WPRIM | ID: wpr-26053

ABSTRACT

Using adipose derived stem cells(ASCs), neurogenic differentiation was induced in a mono layered culture medium containing neuronal induction agents. Cells differentiated to the neuronal cells were observed with a inverted microscope and immunofluorecent study. We made a 15 mm long defect in the sciatic nerve of 14 rats and connected a silicone tube to the defect. Then, we mixed neuronal progenitor cells differentiated from ASCs with collagen gel and grafted them to a group of rats(experimental group) and grafted only collagen gel into another group(control group). In 4 and 8 weeks after the graft, histological observation was made. According to the result, the number and diameter of myelinated axons were significantly increased in the experimental group. In addition, the nerve conduction velocity was improved more in the experimental group and neovascularity also increased. Moreover, reaction with S100 and p75 was observed in regenerated nerves in the experimental group, suggesting that the grafted cells were differentiated into supportive cells such as Schwann's cells. In conclusion, this research proved that ASCs can multiply and differentiate into neuronal cells. If they are grafted into nerve defects, the grafted cells are differ entiated into supportive cells such as Schwann's cells and thus contribute to nerve regeneration. Accordingly, the use of adipose tissue obtained easily without the limitation of donor site can be greatly helpful in treating peripheral nerve defects.


Subject(s)
Animals , Humans , Rats , Adipose Tissue , Axons , Collagen , Myelin Sheath , Nerve Regeneration , Neural Conduction , Neurons , Peripheral Nerves , Sciatic Nerve , Silicones , Stem Cells , Tissue Donors , Transplants
13.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 518-520, 2006.
Article in Korean | WPRIM | ID: wpr-71205

ABSTRACT

PURPOSE: Glomus tumors are uncommon benign neoplasms arising from the neuromyoarterial apparatus, usually seen in the nail bed of fingers. Most of this mass presents typical symptoms such as severe pain, point tenderness and hypersensitivity to cold like neuroma, gout or causalgia. Concerning about the origin, there were few written reports about extra-digit glomus tumor, especially that occurred in the skeletal muscule. METHODS: A 48-year-old female complained of painful tender mass in her right calf aggravated several months ago. Her MRI and femoral angiogram showed a well defined hypervascular tumor such as hemagioma or hemagioendothelioma in the right calf. Surgical treatment was performed, and it proved glomus tumor in soleus muscle histologically. RESULTS: After the operation, patient didn't complain of her symptoms any more and there was no evidence of recurrence during 1 year follow-up period. CONCLUSION: Authors have found only eight cases of intramuscular glomus tumor reported in the literature and present here the ninth case of an intramuscular glomus tumor and first case of soleus muscle.


Subject(s)
Female , Humans , Middle Aged , Causalgia , Fingers , Follow-Up Studies , Glomus Tumor , Gout , Hypersensitivity , Magnetic Resonance Imaging , Muscle, Skeletal , Neuroma , Recurrence
14.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 101-106, 2006.
Article in Korean | WPRIM | ID: wpr-92700

ABSTRACT

Nipple reconstruction is an important step in breast reconstruction after mastectomy. The authors' preferred reconstructive technique is the local C-V flap in case that a small opposite nipple is not adequate for composite graft. This flap produces an excellent reconstruction, but it is not easy to produce an adequate projection and firmness of the nipple. This article describes the technique and experience in nine patients treated over two years with dermis(scar tissue) graft for nipple reconstruction. This is the first report of application of autologous dermis(scar tissue) grafting to reconstruct a nipple primarily after breast mound reconstruction, decreasing the absorption of the reconstructed nipple and increasing the hardness. The dermis(scar tissue) is taken from scar revision and/or dog-ear correction in the second stage operation after free TRAM flap breast reconstruction. And the dermis(scar tissue) graft is inserted vertically between the local flaps and horizontally under the reconstructed nipple base. Between September 2002 and February 2005, nine patients underwent C-V flap with dermis(scar tissue) graft as a part of their nipple reconstruction. The patient's ages ranged from 28 to 55 years old (mean, 41.1 years old). The follow-up period ranged from 5 to 35 months, with an average of 14.5 months. None of the nipples showed skin flap necrosis or local infection, and uneventful wound healing. Our result showed good nipple projection with less absorption and enough firmness. Our experiences shows that dermis(scar tissue) grafts in C-V flap is a very useful method for nipple reconstruction.


Subject(s)
Female , Humans , Middle Aged , Absorption , Breast , Cicatrix , Follow-Up Studies , Hardness , Mammaplasty , Mastectomy , Necrosis , Nipples , Skin , Transplants , Wound Healing
15.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 131-134, 2006.
Article in Korean | WPRIM | ID: wpr-92693

ABSTRACT

The closed suction drain is commonly inserted after various surgical procedures. It has an important role to prevent possible hematoma or seroma that can cause postoperative wound problems. But there is still no consensus on managing the insertion site of suction drain after operation. Suture-tie fixation of drain to skin and classical Y shape gauze dressing is a usually accepted method, but it has many limitations. We introduce a new approach to the care for the insertion site of suction drain by using occlusive transparent film dressing, IV3000(R)(Smith & Nephew, London, UK). By using transparent film, insertion site of drain can be easily checked without removal of dressing. Because it can reduce the tension of suture-tie fixation, it helps to prevent skin injury. Furthermore, occlusive film dressing can block air leakage from insertion site of drain, and the water-proof character of film allows patients to take a shower without dressing change. This new method is more convenient, more efficient, and less harmful to skin than classic one.


Subject(s)
Humans , Bandages , Consensus , Hematoma , Occlusive Dressings , Seroma , Skin , Suction , Wounds and Injuries
16.
Journal of the Korean Cleft Palate-Craniofacial Association ; : 143-145, 2005.
Article in Korean | WPRIM | ID: wpr-220664

ABSTRACT

Kerion celsi is most inflammatory presentation of tinea capitis, which is consisted of pustules and area of crusting, either localized or diffuse. It is considered to be an exaggerated cell mediated response to fungus. It is caused by a number of different fungal species of the genera Trichophyton and Microsporum. In Korea, the vast majority of infections are caused by Microsporum canis, a zoophilic species spread primarily by cats and dogs. This lesion may easily be misinterpreted as bacterial infection, particularly an abscess in the emergency room or outpatient clinic. It's important to keep kerion celsi for differential diagnosis to avoid unnecessary surgical intervention. In this article, we report the case of kerion celsi misinterpreted as bacterial abscess, which developed after trauma.


Subject(s)
Animals , Cats , Dogs , Abscess , Ambulatory Care Facilities , Bacterial Infections , Diagnosis, Differential , Emergency Service, Hospital , Fungi , Korea , Microsporum , Tinea Capitis , Trichophyton
17.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 753-756, 2005.
Article in Korean | WPRIM | ID: wpr-172405

ABSTRACT

In the cases of severe arrythmia and conduction failure, a permanent implanted pacemaker is considered an essential treatment modality with less complication rate, broad indications and low morbidity. However, some pacemakers needs to be removed or replaced due to infection, in need of a lead upgrade, elective replacement, conduction failure or insulation failure. The most common indication for pacemaker extraction is infection. Conservative treatments such as administration of intravenous antibiotics and limitation of debridement are not effective and the removal of the entire pacing system is considered to be the best approach to pacemaker pocket infection. Although a locking stylet, a laser sheath and other newer methods of transvenous lead extraction have been proven to be effective, all leads cannot be removed. Moreover, major complications such as, cardiac tamponade and respiratory arrest during leads extraction procedure should not be ignored. We experienced two cases of exposed pacemakers in the subclavicular region. After removing the pacemaker body, exposed proximal lead was pulled out and cut off. The end of remnant external insulation tube was tied to prevent infection propagation between external insulation tube and inner metalic coil. Wounds were covered by local flap coverage. No other problems were detected during the one-year follow-up. Since there are few reports on lead-preserving method of treating limited infection of exposed pacemakers, we would like to present our new method for treating exposed pacemakers.


Subject(s)
Anti-Bacterial Agents , Arrhythmias, Cardiac , Cardiac Tamponade , Debridement , Follow-Up Studies , Wounds and Injuries
18.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 403-407, 2005.
Article in Korean | WPRIM | ID: wpr-67850

ABSTRACT

Following a transverse rectus abdominis musculocutaneous(TRAM) flap breast reconstruction, denervated state of the flap causes the flap skin prone to thermal injury, calling for special attention. During the last 5 years, 69 breast reconstruction with 72 free TRAM flaps, were performed. Four out of thesse 69 patients sustained burn injury. Heat sources were a warm bag(n=2), heating pad(n=1) and warming light (n=1). The thermal injuries occured from 2 days to 3 months following the reconstruction. Three patients healed with conservative treatment, but one patient required debridement and skin graft. Initially 3 out of 4 patients with the burn had shown superficial 2nd degree burn with small blebs or bullae. However all 4 patients healed with scars. Mechanism of burn injuries of the denervated flap are known to be resulting from; 1) loss of behavioral protection due to denervation of flap with flap elevation and transfer, 2) loss of autonomic thermoregulatory control with heat dissipation on skin flap vasculature contributing to susceptibility of burn injury. 3) changes of immunologic and normal inflammatory response increasing thromboxane, and a fall in substance P & NGF (nerve growth factor). Including the abdominal flap donor site, sensory recovery of the reconstructed breast varies individually from 6 month even to 5 years postoperatively. During this period, wound healing is delayed, resulting in easier scarring compared to that observed in the sensate skin. Patients should be carefully informed and warned of possible burn injuries and taught to avoid exposure to heat source at least until 3 years postoperatively.


Subject(s)
Female , Humans , Blister , Breast , Burns , Cicatrix , Debridement , Denervation , Heating , Hot Temperature , Mammaplasty , Nerve Growth Factor , Rectus Abdominis , Skin , Substance P , Tissue Donors , Transplants , Wound Healing
19.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 12-18, 2005.
Article in Korean | WPRIM | ID: wpr-103393

ABSTRACT

The Transverse rectus abdominis musculocutaneous (TRAM) flap has been commonly used for autologous breast reconstruction. Despite these clinical usefulness, the TRAM flap is prone to partial flap or fat necrosis in especially pedicled flap. To improve flap survival, the surgical delay procedures and pharmacological treatments have been developed. In many studies for the pharmacological treatment, Lipo-PGE1 has demonstrated a marked ability to improve flap survival and it's effect has been proved similar to surgical delay procedure. The purpose of this study is to determine the most effective route of Lipo-PGE1 administration as a pharmacological treatment in TRAM flap of the rat. Fifty male Sprague-Dawley rats weighing 300-350 gm were divided into five groups, One week before flap elevation, Lipo- PGE1(2 microgram/kg) was injected three times in a week and than the left inferior epigastric vessel based TRAM flap (5.0x3.0 cm) elevated; group I: no procedure before flap elevation; group II: intraperitoneal injection; group III: intravenous injection; group IV: subcutaneous injection; group V: topical application. A flap was assessed at postoperative 7 days by comparison of flap survival rate, vessel counts(H-E stain), and vascular endothelial growth factor(VEGF) protein expressed by Western blot. The results demonstrated that the mean percentages of the flap survival area in group III were significantly higher than that of any other group(p<0.05). The vessel counts of all experimental groups were statistically higher than that of control group(p<0.05). Only in group III, the VEGF protein expression was increased significantly than control group and there are no difference in other experimental groups. In conclusion, the intravenous administration of the Lipo-PGE1 is the most effective on flap survival, and the VEGF induced by Lipo-PGE1 has some positive effects on new vessel formation and flap survival.


Subject(s)
Animals , Female , Humans , Male , Rats , Administration, Intravenous , Alprostadil , Blotting, Western , Fat Necrosis , Injections, Intraperitoneal , Injections, Intravenous , Injections, Subcutaneous , Mammaplasty , Myocutaneous Flap , Rats, Sprague-Dawley , Rectus Abdominis , Surgical Flaps , Survival Rate , Vascular Endothelial Growth Factor A
20.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 355-358, 2003.
Article in Korean | WPRIM | ID: wpr-37217

ABSTRACT

The retraction of the upper eyelid is associated with thyroid dysfunction, facial palsy, trauma, and overcorrection of ptosis and also occurs iatrogenically after eyelid or orbital surgery. In this condition, corneal exposure leads to discomfort, epiphora, and corneal irritation. Moreover increased showing of sclera above corneal limbus is considered one of cosmetic defect. Treatment modalities may be either medical or surgical. The medical treatments consists of control of thyroid dysfunction, steroid, sympatholytics. Many authors described surgical correction; recession of levator palpebral muscle or M ller muscle and graft matrix. The difficulties in surgical treatment consist of unpredictability of levator-M ller muscle manipulation, and healing of grafted material. Two patients have been operated with using of septal cartilage-mucosa composite graft. nasal septal cartilage-mucosa composite graft is autologous, firm, thin and harvested easily. The result was satisfactory functionally and aesthetically.


Subject(s)
Humans , Eyelids , Facial Paralysis , Lacrimal Apparatus Diseases , Limbus Corneae , Orbit , Sclera , Sympatholytics , Thyroid Gland , Transplants
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